358O Chemo-responsiveness predictive biomarker discovery for osteosarcoma using microRNA-microarray
نویسندگان
چکیده
منابع مشابه
Early biomarker discovery using microRNA profi ling
microRNA microRNAs are small regulating RNAs that have been shown to play important regulatory roles in most cellular and developmental processes and have been implicated in a large number of human diseases including cancer. Due to their wide-ranging biological potential and the fact that miRNAs seem to be relatively stable in readily available clinical samples, these small 20-22 nt molecules a...
متن کاملSerum microRNA-17 functions as a prognostic biomarker in osteosarcoma
MicroRNAs (miRNAs/miRs) are a class of small noncoding RNA molecules that have important roles in regulating the expression of target genes associated with the development and progression of cancer. The majority of miRNAs are expressed in a highly tissue- and region-specific manner, and released into the bloodstream as a consequences of different diseases. Furthermore, altered levels of miRNAs ...
متن کاملmicroRNA biomarker discovery for asthma in a mouse model
Asthma is a common chronic inflammatory disorder of the airways and is believed to affect more than 300 million people worldwide. It is a heterogeneous disease with several different phenotypes, generally triggered by a combination of environmental and genetic factors. Diagnosis usually depends on pulmonary function tests and can be difficult in young children, since the symptoms resemble viral...
متن کاملClinical trial design for microarray predictive marker discovery and assessment.
Transcriptional profiling technologies that simultaneously measure the expression of thousands of mRNA species represent a powerful new clinical research tool. Similar to previous laboratory analytical methods including immunohistochemistry, PCR and in situ hybridization, this new technology may also find its niche in routine diagnostics. Outcome predictors discovered by these methods may be qu...
متن کاملbiomarker discovery based on hybrid optimization algorithm and artificial neural networks on microarray data for cancer classification
the improvement of high-through-put gene profiling based microarrays technology has provided monitoring the expression value of thousands of genes simultaneously. detailed examination of changes in expression levels of genes can help physicians to have effi cient diagnosing, classification of tumors and cancer’s types as well as effective treatments. finding genes that can classify the group of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2015
ISSN: 0923-7534
DOI: 10.1093/annonc/mdv530.01